Post Tuberculosis Lung Disease in an Elderly Patient With Pseudomonas Infection and Subclinical Hyperthyroidism: a Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Post-tuberculosis lung disease (PTLD) is an underrecognized but increasingly prevalent sequela in TBendemic regions like South Asia. It encompasses structural pulmonary damage and systemic dysregulation, often complicated by opportunistic infections and age-related vulnerabilities. We report the case of a 64 Case Presentation: - year-old Indian female with prior microbiologically cured pulmonary tuberculosis, who presented with mucopurulent cough, orthopnea, and hemoptysis. Imaging revealed fibrotic bronchiectasis with tree-in-bud opacities, and sputum culture isolated Pseudomonas aeruginosa sensitive to meropenem. Concurrently, thyroid function tests showed suppressed TSH (0.007 mIU/L) with preserved FT4, and ultrasonography revealed a TIRADS 4 thyroid nodule. The patient also exhibited early frailty, diastolic dysfunction, and poorly controlled diabetes. She was managed Management: with IV meropenem, nebulized tobramycin, bronchodilators, and supportive care. Endocrine referral was advised for further evaluation of subclinical hyperthyroidism. Functional rehabilitation and discharge planning were coordinated via a multidisciplinary team. This case illustrates the co Conclusion: mplex interplay between PTLD, geriatric pharmacotherapy, endocrine dysfunction, and microbial resistance. It reinforces the need for structured post-TB surveillance and geriatric-integrated care models. The case contributes to evolving global understanding of PTLD as a multisystemic entity, particularly in aging diabetic populations in resource-constrained settings.
Authors: Palakh Lukkad, Vaishali Thakare, Dinesh Gupta, Masum Reza
Institution: D.Y. Patil University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414094875