DNA self-assembly encoding in spatial multi-omics imaging
Year: 2025
Type: article
Abstract: Summary With the development of omics technology, multiple omics techniques have greatly expanded the effective data volume and shown great value in accurately diagnosing major diseases. However, the extremely limited clinical samples and a wide variety of detection biomarkers raise the key technical issue of how to use a small number of samples to achieve multiple biomarker detection. DNA self-assembly (DSA) encoding technology is a controllable technique that can achieve precise regulation of detection signals by combining fluorescent molecular markers based on the high programmability of DNA and the high predictability of the assembled products, playing an important role in the field of target multiplex analysis. Here, we provide a comprehensive overview of DSA encoding in spatial multi-omics imaging, further point out current problems in multiplex analysis, and put forward future research directions.
Source: Cell Reports Physical Science
Authors: Xiaochen Tang, Qizhi Diao, Xiaoli Zhu, Qiuhui Pan
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4414104491