Early adipose tissue wasting in a preclinical model of human lung cancer cachexia
Year: 2025
Type: article
Abstract: (G12D) mice. G12D mice develop CC over a protracted time course and phenocopy tissue and tumor, cellular, mutational, transcriptomic, and metabolic characteristics of human lung CC. G12D mice demonstrate early loss of adipose, a phenotype that was apparent across numerous models of CC and translates to patients with lung cancer. Tumor-released factors promote adipocyte lipolysis, a driver of adipose wasting in CC, and adipose wasting was inversely related to tumor burden. Thus, G12D mice model key features of human lung CC and highlight a role for early tumor metabolic reprogramming of adipose tissue in CC.
Source: Cell Reports
Authors: Deena B. Snoke, Jos L. van der Velden, Emma R. Bellafleur, Jacob S. Dearborn, Sean M. Lenahan, Alexandra E. Beal, Reem Aboushousha, Skyler C.J. Heininger, Jennifer L. Ather, Madeleine M. Mank, Hailey Sarausky, Daniel Stephenson, Julie A. Reisz, Angelo D’Alessandro, Devdoot Majumdar, Thomas P. Ahern, Kaiwen Xu, Kim L. Sandler, Bennett A. Landman, Yvonne M.W. Janssen-Heininger, Matthew E. Poynter, David J. Seward, Michael J. Toth
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: University of Michigan, University of Vermont, National Institutes of Health, Cancer Center, University of Colorado, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1565180698, G2215111373, Michigan Mouse Metabolic Phenotyping Center, G2688814021, G3052115291, G3111867497, G3425209331, Multidisciplinary Training in Lung Biology, G3759388441, G4541629867, Biomedical Data Commons Workbench (BDCW), Development of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategies, G5544006853, G5591400937, G7277816615, G7495326499, G765377740, G8242887288, University of Colorado Cancer Center Support Grant, Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
OpenAlex ID: W4414112184