Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion
Year: 2025
Type: article
Abstract: In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiation potential and guiding progeny to injured areas. Our study provides evidence of alternative migration pathways for newborn neurons in the mouse subcortical forebrain, revealed by administration of a chemotherapeutic agent. This allows a high number of newborn neurons to migrate long distances over an extended period. Notably, a subpopulation of neuroblasts diverts from the canonical SVZ-olfactory bulb (OB) rostral migratory stream toward the striatum (STR), with distinct localization along striatal myelin tracts and through nucleus accumbens (NAc) to the anterior commissure (AC). This neuroblast (NB) rerouting is accompanied by with oligodendrocyte lineage dysregulation and myelin deficits, suggesting a link between ectopic NB presence and observed myelin abnormalities.
Source: Stem Cell Reports
Authors: Irini Thanou, Paraskevi N. Koutsoudaki, Maria Margariti, Federico Luzzati, Sophia Havaki, Vassilis G. Gorgoulis, Dimitra Thomaidou
Institutions: Pasteur Hellenic Institute, National and Kapodistrian University of Athens, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, University of Dundee, Academy of Athens, Manchester Academic Health Science Centre, Ninewells Hospital, University of Surrey, University of Manchester, Biomedical Research Foundation of the Academy of Athens
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Award: G8402658868
OpenAlex ID: W4414112270