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Amyopathic Dermatomyositis Revealing Triple-Negative Breast Cancer: A Case Report and Literature Review

Year: 2025

Type: article

Abstract: Amyopathic dermatomyositis (ADM) is a rare form of dermatomyositis characterized by specific cutaneous lesions without muscle involvement. It can reveal an underlying malignancy, particularly breast carcinoma. We report the case of a 48-year-old woman presenting with a skin eruption suggestive of ADM, preceding the diagnosis of triple-negative breast cancer. Paraneoplastic etiology was confirmed by the presence of anti-TIF1γ antibodies. Management included corticosteroids, intravenous immunoglobulins, and neoadjuvant chemotherapy followed by mastectomy, resulting in rapid improvement in cutaneous manifestations. One-year post-treatment, no recurrence has been observed. This case highlights the importance of systematic oncologic screening in ADM and the value of multidisciplinary care.

Source: Scholars Journal of Medical Case Reports

DOI: 10.36347/sjmcr.2025.v13i09.014

Authors: Adil Chaouni, Hajar Kandoussi, Marouane Oucharqui, Nezha Elbahaoui, Hafid Hachi

Institutions: Mohammed V University, Institut National d'Oncologie

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414137754

FWCI:

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