Quantitative assessment of tissue perfusion in colorectal surgery using ICG fluorescence: first experience
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Evaluation of the clinical efficacy of intraoperative quantitative fluorescence angiography using indocyanine green (ICG) for assessing intestinal wall perfusion to reduce the rate of colorectal anastomotic leakage. A prospective single-center comparative study was conducted, including 81 patients who underwent colon resection with anastomosis. In 42 patients, ICG fluorescence with real-time quantitative perfusion assessment was used. The control group (n = 39) underwent conventional visual assessment of tissue viability. The primary endpoint was the rate of anastomotic leakage; secondary endpoints included the rate of resection line modification and postoperative complications. In the ICG group, the anastomotic leakage rate was 4.8 % compared to 7.7 % in the control group (p = 0.664). Resection line modification based on fluorescence data was required in 14.8 % of patients. The relative risk of anastomotic leakage in the ICG group was 0.62 (95 % CI: 0.12–3.18), indicating a trend toward reduced complications that did not reach statistical significance. Intraoperative ICG fluorescence angiography demonstrates potential clinical benefits in perfusion assessment and resection level modification but did not show a significant reduction in anastomotic leakage rates. The method requires further investigation and standardization of quantitative data interpretation.
Source: Russian surgical journal
Authors: A. A. Zavrazhnov, V. A. Kashchenko, T. S. Lankov, V. D. Kuznetsov, A. D. Novikova, D. S. Pasekova, K. D. Badaev, P. O. Rumyantsev, A. S. Moskalev, V. B. Loshchenov, K. T. Efendiev, A. N. Lavrentyeva, G. A. Smirnov, E. S. Kramorov
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414147284