Work

Assessing the diagnostic capability of the macular ganglion cell complex and retinal fiber layer thickness in glaucoma patients

Year: 2025

Type: article

Abstract: The diagnostic value of macular ganglion cell complex (GCC) and retinal nerve fibre layer (RNFL) thickness in glaucoma is of interest. Using OCT imaging, 90 subjects (45 glaucoma and 45 controls) were studied and the thickness of RNFL and GCC was evaluated. The RNFL was significantly lower in glaucoma patients (71.3 ± 6.5 µm) compared to controls (95.2 ± 5.9 µm, p< 0.001) and so was GCC thickness (72.1 ± 7.3 µm versus 90.6 ± 6.8 µm in controls, p< 0.001). The diagnostic accuracy of RNFL (AUC 0.89) was a bit higher than GCC (AUC 0.87). Combined evaluation enhanced the sensitivity of early glaucoma detection, as well as specificity.

Source: Bioinformation

DOI: 10.6026/973206300212570

Authors: Tripti Thakur, Nishita Yadav, Nazia Imam, Ali M.S.

Institution: Indira Gandhi Institute of Medical Sciences

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414147693