Year: 2025
Type: article
Abstract: This study evaluates the hepatoprotective effects of aqueous (AESC) and ethanolic (EESC) extracts of Sida cordifolia against tartrazine-induced hepato-toxicity in albino rats. Tartrazine, a widely used synthetic food dye, is known to cause oxidative stress and hepatocellular damage. Rats exposed to tartrazine exhibited significant decrease in levels of liver glycogen, protein, amino acids, DNA, RNA and activity of acid phosphatase along with an increase in activity of alkaline phosphatase, indicating liver dysfunction. Treatment with both aqueous and ethanolic extracts of Sida cordifolia significantly mitigated these biochemical alterations and restored hepatic function. The findings suggest that the extracts of Sida cordifolia, confers a protective effect against tartrazine-induced hepatotoxicity, probably through its antioxidant and membrane-stabilizing properties, highlighting its potential as a natural therapeutic agent.
Authors: Prakirnika Mishra, Veena B Kushwaha
Institution: Deen Dayal Upadhyaya Gorakhpur University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414157491