Year: 2025
Type: article
Abstract: Temporal-spatial regulation of somite formation is controlled by the oscillating signals of the segmentation clock, such as Hes7, but how these signals are themselves coordinated remain unclear. In their latest study, Kageyama and colleagues identify Cdh2 as a previously unreported downstream target of Hes7 that is functionally important for the timing of somite formation by both synchronising the oscillations of Hes7 and modulating the oscillations of fellow clock component ppERK. To find out more about the researchers behind the paper and how this story developed, we spoke to first author Xueqi Jia and corresponding author Ryoichiro Kageyama, Director of the RIKEN Center for Biosystems Dynamics Research.
Source: Development
DOI: 10.1242/dev.205200
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4414167167