Spectacular effect of [177Lu]Lu-PSMA-617 therapy in a patient with hormone-resistant prostate cancer after failure of other therapeutic options
Year: 2025
Type: article
Study design: Case Report
Abstract: This research presents the case of a 72-year-old patient with a long history of high-grade prostate cancer (Gleason 8), previously treated with radiotherapy, hormone therapy, and chemotherapy. Due to persistent disease progression and widespread metastases, the patient was enrolled in [177Lu]Lu-PSMA-617 therapy under the Rescue Drug Therapy Access (RDTL) program. Six therapeutic cycles were administered, resulting in marked clinical improvement and a decline in prostate-specific antigen (PSA) levels from 1128.00 ng/mL to 1.68 ng/mL. Positron emission tomography/computed tomography (PET/CT) imaging using [68Ga] Ga-PSMA-11 demonstrated a favorable treatment response, with no significant adverse effects. This case highlights the potential of a theranostic approach in oncology.
Source: Nuclear Medicine Review
DOI: 10.5603/nmr.108217
Authors: Katarzyna Barańska, Katarzyna Niemas, Marta Wojewódzka-Mirocha, Jacek Kabat, Marek Dedecjus
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414167228
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