Measurement equivalence of the UDS version 2.0 and 3.0 neuropsychological batteries
Year: 2025
Type: article
Abstract: INTRODUCTION: The present study examined the dimensional structure of the neuropsychological test batteries from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) versions 2.0 and 3.0 and measurement equivalence across UDS versions and race/ethnicity groups. METHODS: There were 49,895 participants included in the present study. The best-fitting model was developed and tested in separate samples. Multiple group confirmatory factor analysis (CFA) evaluated measurement equivalence across UDS versions and race/ethnicity groups. RESULTS: Results identified a best-fitting four-factor model with residual structure. Multiple group CFA supported partial scalar invariance by UDS version and race/ethnicity group. Regarding race/ethnicity groups, the Language and Attention domains had more non-invariant intercepts, which most affected the White group. DISCUSSION: A four-factor model effectively summarizes the UDS neuropsychological test batteries across UDS versions and race/ethnicity groups. Crucial differences in measurement parameters must be accounted for in studies using these neuropsychological tests as outcomes. HIGHLIGHTS: A four-factor model summarizes cognition across Uniform Data Set (UDS) versions and race/ethnicity groups. Measurement invariance exists across race/ethnicity groups. Model fit differs between cognitively impaired and unimpaired samples. Accounting for differences in measurement parameters across groups is essential. Tailored normative data are crucial for certain UDS tests, including category fluency.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.70720
Institutions: Vanderbilt University, Vanderbilt University Medical Center, University of California San Diego, VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, University of Wisconsin–Madison, Icahn School of Medicine at Mount Sinai, Beth Israel Deaconess Medical Center, Harvard University, University of California, San Francisco, Temple University, University of California Davis Medical Center, University of California, Davis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
Awards: Alzheimer's Disease Research Center, G2673994623, 1Florida Alzheimer's Disease Research Center, Vanderbilt Alzheimer's Disease Research Center, Boston University Alzheimer's Disease Research Center, Yale Alzheimer Disease Research Center, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease, Michigan Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Research Center (KU ADRC), Alzheimer Disease Research Center, Alzheimer's Disease Research Center, Oregon Alzheimer's Disease Research Center, Alzheimer's Disease Research Center, UC Davis Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Indiana Alzheimer's Disease Research Center, Cleveland Alzheimers Disease Research Center, New Approaches to Dementia Heterogeneity, Stanford Alzheimer's Disease Research Center, Mount Sinai Alzheimer's Disease Research Center, Mayo Alzheimer's Disease Research Center, University of Washington Alzheimer's Disease Research Center, New Mexico Alzheimer's Disease Research Center, Duke/UNC Alzheimer's Disease Research Center, Wisconsin Alzheimer's Disease Research Center, Alzheimer's Disease Research Centers, UAB Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, University of Kentucky Alzheimer's Disease Research Center, NORTHWESTERN Alzheimer's Disease Research Center, Penn Alzheimer's Disease Research Center (ADRC), Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center (MADRC), South Texas Alzheimer's Disease Center, Goizueta Alzheimer's Disease Research Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Rush Alzheimer's Disease Research Center
OpenAlex ID: W4414169246