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Anti-MDA5 Positive Dermatomyositis Overlapping with Rheumatoid Arthritis: A Case Report

Year: 2025

Type: article

Abstract: We report a rare case of overlap syndrome between anti-MDA5-positive dermatomyositis (DM) and rheumatoid arthritis (RA) in a 65-year-old woman. Initially diagnosed with RA, the patient later developed characteristic DM manifestations including characteristic DM rash, generalized weakness, poor appetite, and unintentional weight loss. Laboratory findings revealed elevated muscle enzymes, positive anti-melanoma differentiation-associated gene 5 (MDA5) antibody and anti-Ro52 antibodies, and increased anti-citrullinated protein antibodies. The patient showed significant improvement following combination therapy with prednisone and mycophenolate mofetil, highlighting the importance of early recognition and appropriate management of this rare overlap syndrome.

Source: Clinical Cosmetic and Investigational Dermatology

DOI: 10.2147/ccid.s537273

Authors: Fuzhen Yuan, Zhenhua Huang, Eryao Zhang, Dingye Yao, Junsheng Sun

Institutions: Longgang Central Hospital, Guangzhou University of Chinese Medicine

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836