Work

Synthesis, molecular modeling, biological and pharmacokinetic evaluation of hydroxy pyrimidinones and pyrimidinediones as novel LDHA inhibitors

Year: 2025

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2025.118156

Authors: Horrick Sharma, Ty Elliott, Amery Good, Pragya Sharma, Somrita Mondal, Lerin Luckett Chastain, Michael A. Ihnat

Institutions: Southwestern Oklahoma State University, University of Oklahoma Health Sciences Center

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Oklahoma Medical Research Foundation, National Institutes of Health, National Institute of General Medical Sciences

Award: G2532425450

OpenAlex ID: W4414190030

FWCI: 2.278

Cites: 29

Cited by: 7

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