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Clinical Reasoning: A 73-Year-Old Man With Progressive Proximal Muscle Weakness and Binocular Diplopia

Year: 2025

Type: article

Abstract: Progressive weakness and diplopia have a wide differential diagnosis, which can be narrowed by obtaining a detailed history and performing a careful physical examination. It is essential to determine whether these 2 symptoms are due to a single, unifying process or separate processes. We review the case of a 73-year-old man with progressive proximal lower than upper extremity weakness, followed by binocular horizontal diplopia. Clinical history, with attention to rate of progression and associated symptomatology, guided our diagnostic approach and final diagnosis.

Source: Neurology

DOI: 10.1212/wnl.0000000000214173

Authors: Karl J. Wold, Armand Amini, David Bargiela, Sarah Esther Conway, Giovanna Sophia Manzano

Institutions: Mass General Brigham, Harvard University

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4414194386

FWCI:

Cites: 5

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