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Sorting nexins associated with recycling complexes regulate epithelial sodium channel trafficking

Year: 2025

Type: article

Abstract: Cell surface levels of the epithelial sodium channel, ENaC, are controlled by endocytosis and exocytosis pathways. Sorting nexin (SNX) family members facilitate the binding of protein cargo to recycling complexes for sequestration into recycling compartments. We show that knockdown of several SNX proteins decreases ENaC current and cell surface population, and both SNX3 and SNX17 coimmunoprecipitate with ENaC. Our data provide new insights into the control of ENaC cell surface levels and activity.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00088.2025

Authors: Monique L. Scott, Tanya T. Cheung, Matthew J. E. Logue, Feng Zheng, Kirk L. Hamilton, Fiona J. McDonald

Institution: University of Otago

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W4414199434

FWCI:

Cites: 57

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