Targeting Mitochondrial Reactive Oxygen Species: JP4-039’s Potential as a Cardiovascular Therapeutic
Year: 2025
Type: review
Abstract: JP4-039, a mitochondrial-targeted nitroxide, has emerged as a promising candidate in addressing the intricate interplay of reactive oxygen species (ROS) in cardiovascular disease (CVD). Given the substantial mortality and economic burden associated with CVD globally, novel therapeutic strategies targeting oxidative stress hold significant promise. The pathophysiology of CVD encompasses multifaceted mechanisms, including endothelial dysfunction, inflammation, and oxidative stress, where dysregulated ROS levels play a pivotal role. JP4-039, by selectively targeting mitochondrial ROS, offers a targeted approach to mitigate oxidative stress-induced damage in cardiovascular tissue. Current research elucidates the molecular mechanisms underlying JP4-039's antioxidant properties, including its ability to scavenge superoxide radical anions and mitigate oxidative chain reactions within mitochondria. Moreover, preclinical studies highlight JP4-039's efficacy in ameliorating CVD-related pathologies, including atherosclerosis and cardiac hypertrophy, through its antioxidative and anti-inflammatory effects. Future milestones in JP4-039 research involve optimizing its pharmacokinetic (PK) properties and exploring potential synergistic effects with existing cardiovascular therapies, followed by advancing into clinical trials.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm14186465
Institutions: Brown University, Rhode Island Hospital, University of Pittsburgh
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
Awards: G1420732233, G168666665, G2020795389, CardioPulmonary Vascular Biology COBRE, G2096196371, Sub-cellular Targeting of Endothelial ROS in Myocardial Ischemia, G2199054968, G2222624184, G2625561294, G26441607, G3300600345, G3446050087, G3701920199, Sub-cellular Targeting of Endothelial ROS in Myocardial Ischemia, G5264274388, G5521661821, G5652688835, Native Polyphenol-rich Plant Extract Protects Human Coronary Artery Endothelial Cells Against Free Radicals, Effect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular Reactivity, G8836433906, Cardiovascular Surgery Research Training, Vascular Dysfunction in Myocardial Ischemia and Metabolic Syndrome, Stem Cells and Aging, Coronary Vascular Resilience by Modulation of Mitochondrial ROS in Endothelium
OpenAlex ID: W4414204527