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DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization

Year: 2025
Type: article
Abstract: deficiency alleviated ALI by suppressing hepatocyte pyroptosis and blocking communication between macrophages and hepatocytes. Our findings indicate the potential mechanisms of ALI from an intercellular communication perspective, and targeted-inhibition of DLGAP5 and -blockade of hepatocyte-macrophage interaction provide promising strategies for ALI treatment.
DOI: 10.7150/ijbs.118024
Authors: Xianzhi Liu, Zhiyuan Chen, Jun Lin, Yifan Lian, Wenxuan Gan, Huajie Liu, Xingxiang Huang, Jiaxin Mei, Tianrong Ma, Zhi Lu, Wei Zeng, Yihang Gong, Shuai Chen, Weiling He
Institutions: Xiamen University, Zhongshan Hospital of Xiamen University, Tsinghua University, Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Tongji University
Language: English
Subfield: Pharmacology
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4414206169
FWCI: 8.573
Cites: 62
Cited by: 10
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