Work

Activated B cells modulate the maturation of MDSCs via CD36-dependent MHC-II transfer to orchestrate CD4 + Th1-dominant antitumor immunity after cryo-thermal therapy

Year: 2025

Type: article

Abstract: Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has shown great success in treating various cancer types.However, the therapeutic efficacy of ICIs remains unsatisfactory because of the immunosuppressive tumor microenvironment.Cryo-thermal therapy (CTT), a novel tumor ablation approach developed by our laboratory, transforms the tumor immunosuppressive environment into an immunostimulatory environment by activating both innate and adaptive immunity.CTT promotes the differentiation of myeloid-derived suppressor cells (MDSCs) into mature dendritic cells and macrophages, activates antigen-presenting cells and natural killer (NK) cells, and induces Th1-dominant CD4 + T-cell-mediated antitumor immunity in numerous highly metastatic tumor models.However, the role of B cells in CTT-induced antitumor immunity remains unclear despite their critical function in adaptive immunity.Here, in vivo B-cell depletion with anti-CD20 monoclonal antibodies in multiple tumor models revealed that B cells play a crucial role in suppressing tumor metastasis and extending survival.More interestingly, CTT-activated B cells reprogram MDSCs to a mature phenotype through CD36-dependent major histocompatibility complex class II (MHC-II) transfer, resulting in enhanced Th1-dominant CD4 + T-cell responses and CD8 + T-cell cytotoxicity.These findings reveal a novel mechanism of B-cell-mediated modulation of the tumor microenvironment and provide insights into enhancing the efficacy of immunotherapy strategies.

Source: International Journal of Biological Sciences

DOI: 10.7150/ijbs.115232