Work

A new approach to access of 4-organoselenylisoxazoles using the diorganyl diselenide/Oxone® oxidant system

Year: 2025

Type: article

Abstract: In this work, we describe a new protocol to the synthesis of 4-organoselenylisoxazoles using an oxidant system. This transition metal-free method explores the reaction between 1,3-diarylprop-2-yn-1-one O -methyloximes and diorganoyl diselenides in ethanol as solvent, in the presence of Oxone ® as oxidant at 100 °C. A total of thirteen compounds was prepared, including two so far unpublished molecules, in yields ranging from 42 to 99%. Furthermore, some control experiments and a scale-up study were performed, to demonstrate the usefulness of this methodology.

Source: Discover Chemistry.

DOI: 10.1007/s44371-025-00285-x