Work

Intramolecular Heck Reactions of Cyclic Sulfonamides: Regiochemical Trends and Reductive Cleavage

Year: 2025

Type: article

Abstract: The synthesis of a new class of cyclic sulfonamides (sultams) and their subsequent conversion into substituted N‐heterocycles is reported. Methyl‐substituted tetrahydropyridine and tetrahydro‐azepine Heck precursors are prepared and cyclized to provide a variety of regioisomeric products. Thereafter, the cyclic sulfonamide products are subjected to sulfonyl cleavage to provide several novel phenyl‐substituted N‐heterocycles, each containing functional groups useful for further functionalization.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500647

Authors: Hanno Stanley, Anna Tews, Kimberly Geoghegan, Paul Evans

Institution: University College Dublin

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: National University of Ireland