Evaluation of the alpha-glucosidase and alpha-amylase inhibitory potential of the Costus speciosus(J. Koenig) Sm. harvested in Vietnam
Year: 2025
Type: article
Abstract: This study aimed to evaluate the inhibitory activity of α-glucosidase and α-amylase enzymes using aqueous and 40% ethanol extracts from the aerial parts of Costus speciosus harvested in Binh Phuoc province, tested in vitro.The enzyme inhibition activity was measured using α-amylase from porcine pancreas and α-glucosidase from Saccharomyces cerevisiae.Results showed that both the aqueous extract and the ethanol extract from the aerial parts of Costus speciosus showed significant α-glucosidase inhibition, with IC50 values of 18.51 and 77.25 µg/ml, respectively.Both extracts demonstrated lower IC50 values compared to the positive control, acarbose (IC50=122.20µg/ml).For α-amylase inhibition, the aqueous extract and ethanol extract exhibited relatively low inhibition rates of 3.79 and 3.12%, respectively, compared to acarbose, which had an IC50 of 50 µg/ml for α-amylase inhibition.The study demonstrated that the aqueous and ethanol extracts of the Costus speciosus aerial parts exhibited in vitro inhibitory effects on α-glucosidase.However, the extracts showed poor inhibitory effects on α-amylase activity.These findings provide additional
Authors: Oanh Hoang Hua, Nu Thi
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414214869
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