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Asymptomatic Complete Heart Block in an Adult with Down’s Syndrome and Structurally Normal Heart: A Rare Association

Year: 2025

Type: article

Abstract: ABSTRACT: Down's syndrome (DS) is caused by an extra copy of the chromosome 21. Patients with DS have short stature, intellectual impairment, and characteristic physical features. Cardiovascular disease is the leading cause of morbidity and mortality in patients with DS. An estimated 40%-60% of DS patients have congenital heart disease (CHD). Cardiac conduction disturbances in association with CHD have been described in patients with DS. However, isolated cardiac conduction defect is exceptionally rare in DS, and we report an unusual case of asymptomatic complete heart block in an adult case of DS with structurally normal heart and review the literature about the conduction disturbances in DS.

Source: Annals of African Medicine

DOI: 10.4103/aam.aam_234_25

Authors: Sangram Mangudkar, Nallani Chakravarthi Sai Sirisha, Vijayashree Gokhale, Divam Prakash Singh

Institutions: Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414215866

FWCI:

Cites: 6

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