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Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. Int. Ed. 41/2025)

Year: 2025

Type: article

Abstract: Neuromelanin is a pigment in the brain and an effective metal chelator. It is likely a crucial factor in the viability of neurons, which has sparked interest in MRI biomarkers for neurodegenerative diseases. In their Research Article (e202509102), Harald E. Möller and co-workers demonstrate remarkable complexity of the binding of Fe and Cu to synthetic neuromelanin analogues, with different binding sites, competition, and intricate magnetic properties, all of which affect the proton relaxation of surrounding water, the main contrast mechanism in MRI.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202519533

Authors: Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller

Institutions: Max Planck Institute for Human Cognitive and Brain Sciences, University of Pavia, Leipzig University, Institute of Biomedical Technologies, National Research Council

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4414216960

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