The active monitoring of oxytocin research evidence (AMORE) platform
Year: 2025
Type: review
Abstract: Oxytocin, an evolutionarily conserved neuropeptide, plays a crucial role in various physiological and behavioural processes, offering potential therapeutic benefits for several psychiatric and neurodevelopmental conditions. Despite its promise, oxytocin research has been marked by inconsistent results concerning its therapeutic applications and underlying mechanisms. Performing a systematic review and meta-analysis is a popular approach to shed light on mixed findings in a body of literature; however, they can become quickly outdated as new evidence becomes available. Given these challenges, research on the links between oxytocin and biobehavioural outcomes is ideally positioned for the adoption of 'living' meta-analyses, which allow for the continuous integration of new data and updated conclusions. Here we introduce the Active Monitoring of Oxytocin Research Evidence (AMORE) platform (https://amore-project.org), which is a hub that aggregates articles and materials associated with living meta-analyses for biobehavioural oxytocin research in humans. Developed through consensus among 24 expert researchers, a standardized framework was established that either requires or recommends practices ensuring transparency and rigor in living meta-analyses featured on the AMORE platform. Overall, AMORE has been designed to advance human oxytocin biobehavioural research by the timely integration of emerging evidence through transparent living meta-analyses. To date, two living meta-analysis projects at different stages of publication are hosted on AMORE, demonstrating the platform's practical application.
Source: Psychoneuroendocrinology
Authors: Ingebjørg A. Iversen, Kaat Alaerts, Marian Bakermans-Kranenburg, Benjamin Becker, Robert James Blair, Jennifer A. Bartz, Jessica J. Connelly, Beate Ditzen, Natalie C. Ebner, Heemin Kang, Elizabeth A. Lawson, Nicole Nadine Lønfeldt, Matthijs Moerkerke, Christian Montag, Anna-Rosa Cecilie Mora-Jensen, Marilyn Horta, Leehe Peled-Avron, Tanya L. Procyshyn, Alina I. Sartorius, Dirk Scheele, Ekaterina Schneider, Constantina Theofanopoulou, Hidenori Yamasue, Daniel S. Quintana
Institutions: University of Oslo, KU Leuven, Universidad San Sebastián, ISPA - Instituto Universitário, William James Center for Research, University of Hong Kong, University of Copenhagen, McGill University, University of Virginia, University of Zurich, University of Florida, Harvard University, Massachusetts General Hospital, Mental Health Services, Copenhagen University Hospital, Ghent University, University of Macau, Moffitt Cancer Center, Bar-Ilan University, University of Cambridge, Ruhr University Bochum, Emory University, New York University, Rockefeller University, Hamamatsu University School of Medicine, Oslo University Hospital
Language: English
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,830
Awards: G4375092791, G462532508, G540898868
OpenAlex ID: W4417066358