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Case Report: Functional MR imaging of alveolar soft part sarcoma

Year: 2025

Type: article

Abstract: This study presents a rare case of acinar soft tissue sarcoma and provides a detailed analysis of its multi-parameter quantitative functional MRI (fMRI) characteristics. The patient, a 16-year-old male, was diagnosed with acinar soft tissue sarcoma after presenting with a progressively enlarging mass in the right thigh. To determine the extent and nature of the lesion, MRI examinations were performed using conventional plain scans, contrast-enhanced scans, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and intravoxel incoherent motion (IVIM) for quantitative analysis. Functional MRI imaging not only provides crucial diagnostic and differential diagnostic information for acinar soft tissue sarcoma, but also reveals through DCE-MRI and IVIM imaging indicators that ASPS exhibits high cellular density, increased vascular permeability, and abundant neovascularization. The local microcirculation characteristics offer vital insights into the tumor's biological behavior and prognosis. Furthermore, functional MRI aids in precise diagnosis while providing references for surgical planning, postoperative adjuvant therapy, long-term follow-up evaluation, and recurrence risk prediction.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1602577

Authors: Jie Li, Zhaoyang Yang, Jiuming Jiang, Lihua Gong, Meng Li

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Cancer Hospital of Chinese Academy of Medical Sciences

Language: English

Topic: MRI in cancer diagnosis

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801