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Metabolic Profiling of Serum & Saliva in OSCC: A Combined Biofluid Approach for Enhanced Biomarker Discovery using 1H NMR.

Year: 2025

Type: conference-paper

Abstract: Motivation: Early detection of oral cancer remains challenging. There's a critical need for accessible, non-invasive biomarkers that can improve early diagnosis, helping to enhance survival rates and treatment outcomes for Oral Squamous Cell Carcinoma (OSCC) patients. Goal(s): To identify potential diagnostic biomarkers for OSCC by profiling metabolic changes in serum and saliva. Approach: Using 1H NMR metabolomics, saliva and serum were analyzed to identify pathway and metabolic alteration in OSCC patients compared to controls. Results: Elevated methanol and disrupted phenylalanine, tyrosine, and tryptophan pathways were observed in both biofluids, indicating potential OSCC biomarkers. The combined biofluid approach shows promise for non-invasive early OSCC detection. Impact: This study highlights the potential of using combined serum and saliva metabolomic profiling as a non-invasive approach to identify reliable biomarkers for early OSCC detection, offering a promising tool for improved diagnostic accuracy and timely intervention.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2025/3019

Authors: Shivani Tripathi, Nisha Chauhan, Sandeep Bhoriwal, Sadhana Kumari, Pankaj ., Ekta Dhamija, S Senthil Kumaran, Renugopalakrishnan Venkatesan, Bansi Malhotra, Ramasamy Paulmurugan

Language: English

Topic: Metabolomics and Mass Spectrometry Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414233757

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