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Investigation of cardiac-rhythm related differences in hemodynamics using a 3D universal left atrial coordinate system dedicated to 4D Flow MRI

Year: 2025

Type: conference-paper

Abstract: Motivation: 4D Flow MRI offers valuable hemodynamic information in individual subjects. Yet, understanding the hemodynamic involvement in atrial fibrillation (AF) requires inter-subject comparisons that are difficult due to the high variability and complex morphology of the left atrium (LA). Goal(s): Construct a 3D universal left atrial coordinate system (3D-ULAC) dedicated to 4D Flow MRI and use it to explore cardiac-rhythm related differences in LA hemodynamics. Approach: Paroxysmal AF and age-matched healthy subjects underwent 4D Flow MRI. LA hemodynamic parameters of each subject were transported to the same target 3D-ULAC for inter-group comparison. Results: Qualitatively different flow patterns were observed on group average hemodynamic maps. Impact: The volumetric universal coordinate system for the left atrium enabled straightforward comparisons of blood flow parameters between subjects. The method may prove valuable in larger populations studies to highlight pathology specific flow patterns and identify individuals with significantly different patterns.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2025/5269

Authors: Monica Sigovan, Sara Boccalini, Marta Beghella, Vicky Wang, Ayah Elsayed, Martyn Nash, Nicolas Duchateau, Philippe Douek, Philippe Chevalier

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4414234266

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