Stability of single-subject estimation of glutamate and GABA dynamics in concurrent fMRI-fMRS at 7 T
Year: 2025
Type: conference-paper
Abstract: Motivation: Measuring neurochemical dynamics, particularly the concentrations of GABA and glutamate, at the single-subject level remains challenging due to the low SNR when a small number of transients are used in the averaging window. Goals: To assess the impact of different averaging window sizes on the stability of GABA and glutamate concentration estimates during the time-course of a visual stimulation experiment. Approach: We analyzed the data using various averaging window sizes to evaluate their effect on concentration stability. Results: Detecting single-subject changes in Glutamate and GABA remains challenging, even with a window size of 16 representing the largest practical window size in our experiments. Impact: In single-subject fMRS, choosing averaging window sizes with sufficient SNR is important for reliable measurements of glutamate and GABA dynamics. Further technical development both on the analysis side (temporal fitting) and acquisition side (real-time frequency drift correction) should be explored.
DOI: 10.58530/2025/4827
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Fetal Neuroprotection by choline supplementation in heavy drinking pregnant women, Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants, Sequence-universal high-frequency prospective MRI motion correction with navigators, Computeserver Structural &Functional Image Analysis, Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence, Center for Functional Imaging Technologies, A Storage Area Network for Structural and Functional Image Analysis, Comprehensive prospective correction of head motion in functional MRI, Neural correlates of in utero HIV and ART exposure: early childhood follow-up of a prospectively recruited cohort, Development of multinuclear MRI for image guided therapy of glioma patients, Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients, Robust Precision Mapping of Cortical and Subcortical Brain Metabolic Signatures in AD, Silicon Graphics Prism Extreme 128P/1TB
OpenAlex ID: W4414234620
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