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Metabolism in the human brain following oral consumption of a keto-ester for applications in alcohol use disorder (AUD) with 1H-MRSI

Year: 2025

Type: conference-paper

Abstract: Motivation: Oral consumption of the ketone-monoester (R)−3-hydroxybutyl-(R)−3-hydroxybutyrate (HBHB) raises the plasma ketone-body β-hydroxybutyrate (BHB), providing a means to study ketone body metabolism. HBHB Hydrolysis however produces BHB and 1,3-butanediol, which share prominent spectral signatures complicating metabolite quantification. Goal(s): Investigate feasibility and robustly detection of BHB. Subsequently, investigate brain ketone-body metabolism in alcohol use disorder (AUD). Approach: HBHB was administered orally, and brain metabolism was monitored over 90 minutes using MRS with 1,3-butanediol included as a reference spectrum. Results: Combined BHB and the co-edited 1,3-butanediol were robustly detected, though separate quantification of BHB and 1,3-butanediol was challenging due to low concentrations. Impact: Accurate BHB quantification is critical to evaluate BHB transport into the brain post-keto-ester consumption. A modified J-difference editing strategy is expected to mitigate shortcomings to investigate BHB transport to assess disease severity and gain insights related to craving in AUD.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2025/0612

Authors: Mansimran Virk, Razi Kitaneh, Marcella Mignosa, Scott McIntyre, Terence Nixon, Kelly DeMartini, Stephanie O’Malley, John Krystal, Henk De Feyter, Gustavo Angarita, Graeme Mason, Robin de Graaf, Chathura Kumaragamage

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4414238560

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