Work

2-(Methoxycarbonyl)thiophen-3-yl-diazonium Salts: Efficient Precursors for the Formation of C–C Bonds in Thiophene-Containing Heterocyclic Systems

Year: 2025

Type: article

Abstract: A first application of 2-(methoxycarbonyl)thiophen-3-diazonium salts in the halothienylation of α,β-unsaturated functionalized compounds under Meerwein reaction conditions is presented. This process provides thiophene-containing building blocks that can then undergo cyclization reactions with bisnucleophiles to synthesize thiophene-3-yl-containing heterocyclic systems. In this way, substituted 2,3'-bithiophene compounds and thiophene-3-yl derivatives of 2-aminothiazole, 2-aminoselenazole, thiazolidine, and selenazolidine can be efficiently prepared.

Source: Molecules

DOI: 10.3390/molecules30183758

Authors: Yurii V. Ostapiuk, Oksana V. Barabash, Mary Y. Ostapiuk, Mykola Kravets, Andreas Schmidt, Mykola D. Obushak

Institutions: Lviv University, Institute of Physical Chemistry, Polish Academy of Sciences, Clausthal University of Technology

Language: English

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: Science Foundation Ireland, Ministry of Education and Science of Ukraine