High-pressure solubility of methadone hydrochloride in supercritical CO2: Experimental investigation and correlations
Year: 2025
Type: article
Abstract: Exact drug solubility determination and modeling in supercritical carbon dioxide (SC-CO2) would address the optimal experimental conditions for processing substances with supercritical fluid (SCF). In this investigation, for the first time, the solubility of Methadone hydrochloride is measured and modeled using the perturbed chain-statistical associating fluid theory (PC-SAFT) equation of state (EoS) alongside a set of eight semi-empirical models. The 24 experimental data points were obtained at pressures ranging from 120 to 270 bar and temperatures between 308 and 338 K. The minimum and maximum mole fractions observed were 1.74 × 10-5 and 4.67 × 10-5, respectively, occurring within these ranges. The results indicate that both pressure and temperature significantly affect Methadone hydrochloride solubility, so that as both pressure and temperature rise, the solubility increases. Among the models, the Chrastil model and PC-SAFT EoS exhibited the lowest absolute average relative deviation (AARD) % of approximately 6.71% and 9.73%, respectively. Finally, the enthalpies of the methadone hydrochloride/CO2 binary system were calculated as = 29.14 kJ/mol, = 23.04 kJ/mol, = 40.61 kJ/mol, = -11.47 kJ/mol, and = -17.57 kJ/mol.
Source: Arabian Journal of Chemistry
Authors: Gholamhossein Sodeifian, Hamidreza Bagheri, Shima Golshani, Hamidreza Bakhshaei Ghorogh Aghaei, Adel Noubigh, Mohammadreza Rashidi-Nooshabadi
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $1,490
OpenAlex ID: W4414248541