Work

Cell-Penetrating Peptoids: A Dual Functional Strategy for Upcoming Neuroregeneration Application

Year: 2025

Type: editorial

Abstract: Effective therapies for neurological conditions are a significant challenge since limited capacity of neurons for regeneration affects neuronal recovery. Despite their ineffective in vivo direct development into neurons, human mesenchymal stem cells (hMSCs) exhibit therapeutic promise through immunological regulation, neuroprotection, and improvement of endogenous repair. A promising strategy is to convert hMSCs into functional neurons using peptoids that also possess cell-penetrating abilities. Therefore, developing cell-penetrating peptoids that combine effective cellular uptake with neural differentiation induction could significantly progress neuroscience research and neuroregenerative treatments.

Source: ACS Chemical Neuroscience

DOI: 10.1021/acschemneuro.5c00693

Authors: Pratikshya Paudel, Rupali Kaur, Prabir Kumar Gharai

Institution: Oklahoma State University

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500