Work

Emerging Mechanisms Linking High-Fat Diet and Endometrial Cancer: Insights into the Role of Gut Microbiota and Metabolic Dysregulation

Year: 2025

Type: article

Abstract: High-fat diet (HFD) consumption has been recognized as a significant risk factor for the development of endometrial carcinoma (EC). Emerging research highlights gut microbiota as crucial mediators of HFD-induced systemic effects, which not only promote metabolic disorders such as obesity, insulin resistance, and systemic inflammation but also lead to profound alterations in gut microbiota composition. These changes subsequently influence estrogen metabolism, inflammatory signaling pathways, and endometrial remodeling, thereby exacerbating cellular proliferation and atypical changes within the endometrium. The underlying mechanisms may involve dysbiotic shifts in intestinal flora that contribute to increased endotoxemia, compromised intestinal barrier function, and chronic low-grade inflammation. This review synthesizes current findings on how HFD-induced gut microbiota dysbiosis and metabolic dysregulation contribute to the pathogenesis of EC while highlighting potential preventive and therapeutic strategies.

Source: Serican Journal of Medicine

DOI: 10.17161/sjm.v2i4.24349

Authors: Kana Wang, Kunang Liu, Lin Li, Dongxia Ge, Zongbing You

Institution: Tulane University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Tulane University, Natural Science Foundation of Sichuan Province