The association of eicosanoids with lung structure and function: Findings from the Multi-Ethnic Study of Atherosclerosis lung study and Framingham Heart Study
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Eicosanoids are bioactive signaling lipids that have roles in airway remodeling, smooth muscle hypertrophy, emphysema and pulmonary fibrosis via mediation of pro- and anti-inflammatory pathways. Specific eicosanoids have been associated with lung diseases such as asthma and pulmonary fibrosis, yet their association with lung function more broadly is not completely understood. We aimed to investigate the association of eicosanoids and related metabolites with early changes in lung function and structure. METHODS: We performed comprehensive profiling of over 250 eicosanoids and eicosanoid-related metabolites using directed non-targeted mass spectrometry in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study with independent validation in the Framingham Heart Study (FHS). We performed cross-sectional analysis of the associations between metabolites and lung function as assessed by spirometry and quantitative lung measures on computed tomography (CT). RESULTS: Among 3384 participants (mean age 63 ± 10 years, 51% women), 51 metabolites were associated with lung function in MESA Lung (22 with % predicted FEV1, 18 with % predicted FVC, and 25 with FEV1/FVC ratio), with 24 validated among FHS participants. Of these 51 metabolites, 27 were associated with obstructive lung physiology, including linoleic acid derivatives (9-HODE) and other long-chain fatty acids (hydroxyhexadecanoic acid, hydroxyoctadecanoic acid) associated with higher odds. Fourteen metabolites were associated with restrictive physiology, including putative dihydroxy-20:3 and an LTB3 analog associated with lower odds, and omega-3 fatty acids (EPA, stearidonic acid) associated with higher odds. CONCLUSIONS: Specific eicosanoids and eicosanoid-related metabolites including linoleic acid derivatives and long-chain fatty acids were associated with obstructive, and leukotrienes and omega-3 fatty acids with restrictive lung physiology. These findings highlight bioactive lipids involved in both pro- and anti-inflammatory pathways as potential influencers of lung function and may serve as future therapeutic targets early in lung disease development.
Source: PLoS ONE
Institutions: Beth Israel Deaconess Medical Center, Duke University Hospital, University of California San Diego, University of Iowa, University of Iowa Health Care, Boston University, Framingham Heart Study, Broad Institute, Harvard University, Massachusetts Institute of Technology, Northwestern University, Columbia University Irving Medical Center, Columbia University, Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1019010090, G1261793039, G1269631540, G1276754516, G1294553593, G1412221515, G1446319095, G1490530680, G1516086731, G1522144118, G1539384734, G1558725192, G1610333345, G1640378483, G1723146954, G1740741465, G1742652086, G17630474, G1802610309, G1803853571, Wake Forest Clinical and Translational Science Award, G1912130661, G1983464145, G2095942735, G2144938473, G22458031, G250621538, G2580996367, G2726417417, G2779429302, G278200998, G2837638605, G2895743475, G290884426, G2917396017, G291913881, G296458788, G3047789618, G3093995152, G3161396180, G3252259982, G3563251057, G3570589137, G3581052147, G3595232572, G3667269547, G3676546685, G3819938352, Eicosanoid Profiles as Determinants of HFpEF, Novel Quantitative Emphysema Subtypes in MESA and SPIROMICS, G3990748671, G4036023366, G4086764833, G4118980254, G4120448791, G4186273061, G4309390892, G4345352953, G4401650913, G4436208180, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G4497505643, G4563812999, G4590187187, G4986157935, G5075046117, G5108002584, G514410172, G5285871103, G5576653721, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G5653954166, G566787130, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY, Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes, Institute for Clinical and Translational Research, G6443373778, G66341962, G6742279884, G6798586005, G6856766826, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY, G7166352866, G733687432, G7462069030, G78770644, G7924587209, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G805458286, Clinical and Translational Science Award, G8145863542, G818308888, Mentoring in Patient-Oriented and Translational HFpEF Research, G842756795, G8638601890, G8683204365, G8761005068, G8852914737, Combined Cardiopulmonary Failure in COPD: SPIROMICS HF, G9000006353, G9000025517, G9000065698, G9000124674, Precision phenotyping of emphysema in the elderly: the MESA Lung Study, Endothelial Cell Health Across the Spectrum of Cardiometabolic Disease, Long-Term Endothelial Effects of COVID-19 in Obesity, Airway trees in the Anthropocene: Defining resilient airway trees and identifying the candidate mechanisms and etiologic factors that increase susceptibility to tobacco smoke and air pollution, Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension, G991334795
OpenAlex ID: W7166645348