Work

Electrophysiological evidence of Hebbian plasticity in awake adult rats

Year: 2025

Type: article

Abstract: Hebbian stimulation, based on spike timing-dependent plasticity (STDP), has been used to enhance functional recovery in spinal cord injury (SCI). Here, we show that paired stimulation following STDP principles can bidirectionally modulate motor-evoked potential size in the soleus muscle of awake rats. This rat model provides a valuable platform for exploring combination therapies to improve motor recovery in SCI and other neurological disorders.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00129.2025

Authors: Siddharth S. Gaikwad, Yi Chen, Bing Chen, Wil H. D. Bogue, Giuseppe Scesa, Matthew S. Neehouse, Theresa M. Vaughan, Jonathan S. Carp, Martin Oudega, Jonathan R. Wolpaw, Monica A. Perez

Institutions: Shirley Ryan AbilityLab, Albany Stratton VA Medical Center Albany, Northwestern University, Edward Hines, Jr. VA Hospital, State University of New York, University at Albany, State University of New York

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G199702147, G2272472098, G2802977549, G3178867607, G3896271538, G5452189506, G569173182, G9000057635, G9000147808, G9000331328, Paired Stimulation Plasticity for Motor Recovery

OpenAlex ID: W4414263187

FWCI: 0.581

Cites: 46

Cited by: 1

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