Work

Phrenic long-term facilitation following severe acute intermittent hypoxia is preserved in geriatric male rats

Year: 2025

Type: article

Abstract: We report new findings that advance our understanding of how cellular mechanisms underlying respiratory motor plasticity shift with age. Age-related shifts in the magnitude or mechanism driving plasticity have major clinical relevance as we work to translate AIH for therapeutic benefit in conditions such as chronic spinal cord injury or ALS, where subjects in ongoing clinical trials are often males of advanced age.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00260.2025

Authors: Kayla A. Burrowes, Alexandria B. Marciante, Gordon S. Mitchell

Institution: University of Florida

Language: English

Topic: Neuroscience of respiration and sleep

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute