EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch
Year: 2025
Type: article
Abstract: Collectively, these findings define a novel "microbiota-inosine-EZH2" axis in depression pathogenesis and highlight EZH2 degradation as a promising therapeutic strategy for microbiota-associated neuropsychiatric disorders.
Source: Theranostics
DOI: 10.7150/thno.120824
Authors: Sen Zhu, Xuan Li, Ying Yu, Xiaoyi Han, Fang Yang, Mengxi Lu, Gaole Dai, Liang Guo, Dan Xu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4414269268