Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing
Year: 2025
Type: article
Abstract: CMS orchestrated the Piezo1/ATP-driven metabolic-mitochondrial axis to enhance ADSCs oxidative stress resistance by coupling metabolic reprogramming with mitophagy activation. This mechanometabolic interaction identifies mechanical signaling as a direct regulator of cellular bioenergetics, offering a translatable strategy to engineer antioxidant-functionalized stem cells for regenerative therapies.
Source: Theranostics
DOI: 10.7150/thno.118364
Authors: Yujie Xiao, Zhijun Shi, Yixuan Yuan, Danna Yao, Rongqin Feng, Yue Zhang, Deli Zhao, Hao Zhang, Panpan Sun, Yang Liu, Yan Li, Xuefeng Shen, Zhantong Wang, Dahai Hu, Hao Guan, Hongtao Wang
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4414269348