Work

Bioactive pure zinc anchor on promoting tendon bone healing

Year: 2025

Type: article

Abstract: Over the past few decades, extensive research has been devoted to developing biodegradable materials for tendon suture fixation. However, achieving an optimal balance among biocompatibility, mechanical properties, and the capacity to promote tendon-bone enthesis integration remains a significant challenge, limiting clinical translation. To overcome these limitations, we developed a pure zinc (Zn) anchor. In vitro studies demonstrated its excellent biocompatibility and robust osteogenic, chondrogenic, and tenogenic potential. In vivo studies, we compared the therapeutic efficacy of pure Zn anchors with Ti6Al4V (TC4) anchors in a rabbit model of rotator cuff tear repair. The results revealed that pure Zn anchors not only accelerated tendon-bone enthesis healing but also eliminated imaging artifacts associated with conventional metallic implants, highlighting their promising clinical utility for orthopedic applications.

Source: Materials Today Advances

DOI: 10.1016/j.mtadv.2025.100615

Authors: Hao Sun, Fan Yang, Hongyao Zeng, Feixue Yang, Hongjie Huang, Jianquan Wang

Institutions: Peking University Third Hospital, Peking University

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790