Work

Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers

Year: 2025

Type: article

Abstract: Significance Current systems for diffuse optical tomography (DOT) are unsuitable for clinical applications on acute traumatic brain injury (TBI) patients while in the intensive care unit (ICU). Aim To develop and test a method for DOT recordings suitable for TBI patients in the ICU. This method is based on measurements and co-registration using 3-D optical scans, and the acquisition of optical data using a custom-made helmet which would enable a multimodal (invasive and non-invasive) neuromonitoring. Approach Probe displacements compared to electromagnetic digitization co-registrations were assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy (fNIRS), the optical signal in the intracranial (ICT) and extracranial tissues (ECT) was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830 nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment. Results The results showed an average error in probe displacement of 5.5 mm, a sufficient capacity to isolate oxyhemoglobin O2Hb (p=6.4·10 -6 ) and total hemoglobin HbT (p=2.8·10 -5 ) in the ICT from the ECT, and to follow the changes of hemoglobin in the ICT during the VM (O2Hb, p=9.2·10 -4 ; HbT, p=1.0·10 -3 ). Conclusions The developed approach appears to be suitable for use on TBI patients in the ICU.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.30.s2.s23912