Work

Association of Pan-Immune-Inflammation Value with All-Cause and Cardiovascular Mortality in Survivors of Myocardial Infarction: NHANES 2001–2018 Analysis

Year: 2025

Type: article

Abstract: BACKGROUND: Inflammatory responses critically impact long-term outcomes in myocardial infarction (MI) survivors, yet few biomarkers comprehensively evaluate systemic immune-inflammatory status. This study assessed the prognostic utility of a novel marker-the pan-immune-inflammation value (PIV)-for predicting all-cause and cardiovascular mortality post-MI. METHODS: Using the National Health and Nutrition Examination Survey data (2001-2018), 1559 MI survivors were included. PIV was calculated as (neutrophils × platelets × monocytes)/lymphocytes. Weighted Cox models assessed the association between log-transformed PIV (LnPIV) and mortality. Restricted cubic spline (RCS) models explored non-linear dose-response relationships, and predictive performance was evaluated via time-dependent ROC analysis. RESULTS: = 0.0471). When LnPIV ≥ 5.59, each unit increase was associated with an 85% (HR = 1.85, 95% CI: 1.49-2.28) higher all-cause mortality risk; for cardiovascular mortality, the risk increased by 77% (HR = 1.77, 95% CI: 1.20-2.63) when LnPIV ≥ 5.68. Time-dependent ROC analysis confirmed strong prediction above these thresholds. CONCLUSION: PIV demonstrates threshold-dependent mortality risk stratification in MI patients, particularly effective in high-inflammatory subgroups, offering a potential tool for personalized risk stratification.

Source: Journal of Cardiovascular Development and Disease

DOI: 10.3390/jcdd12090363

Authors: Qingyi Liu, Wenling Yang, Ruiyu Zhang, Xiaopeng Guo, Yumiao Wei

Institutions: Wuhan Union Hospital, Huazhong University of Science and Technology

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258