The effect of dexamethasone on treatment outcomes in patients with cerebral contusion and comorbid novel coronavirus infection (COVID-19)
Year: 2025
Type: article
Abstract: Introduction. The problem of treating cerebral contusions in combination with a novel coronavirus infection is highly relevant in modern medicine and holds significant socio-economic importance.Methods and materials. During the study period (January 2021 – January 2023), 185 patients aged 18 to 80 years (median 38.5 years) with verified cerebral contusions (subarachnoid hemorrhage, contusion-hemorrhagic foci, subdural and epidural hematomas, traumatic intracerebral hematomas) confirmed by CT scans, and a diagnosis of «novel coronavirus infection» verified via clinical, laboratory, and instrumental data (PCR swab for SARS-CoV-2, chest CT findings), were examined at the St. Petersburg State Budgetary Healthcare Institution «Alexandrovskaya Hospital».Results. The administration of glucocorticoids in patients with moderate to severe cerebral contusions combined with COVID-19 reduces hypoxia, cerebral edema, and consequently shortens the regression time of generalized and focal neurological symptoms. A reduction in hospitalization duration was observed. To date, this method can be effectively used in treating patients with traumatic brain injury (TBI) and COVID-19. The approach is promising but requires further randomized studies.Conclusion. Dexamethasone reduces mortality and accelerates recovery in patients with cerebral contusions combined with COVID-19.
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414285164