Work

Porphyria cutanea tarda

Year: 2025

Type: article

Abstract: Porphyria cutanea tarda (PCT) is caused by decreased activity of uroporphyrinogen decarboxylase (UROD) due to various susceptibility factors, here among pathogenic variants in UROD and the presence of iron overload. Porphyrins are sensitive to light and cause cutaneous symptoms in the form of blisters and ulcers on sun-exposed skin. This review gives an update on diagnosing, monitoring and the treatment of PCT. PCT is often effectively treated with venesection or/and low-dose hydroxychloroquine. Additionally, patients must be informed about sufficient sun protection and reduction of susceptibility factors.

Source: Ugeskrift for Læger

DOI: 10.61409/v11240832

Authors: Josephine Mistegård, Anne Lindegaard Christiansen, Christian Vestergaard, Hans Christian Wulf, Henrik F. Lorentzen

Institutions: Odense University Hospital, Sygehus Sønderjylland, Aarhus University Hospital, Bispebjerg Hospital, Copenhagen University Hospital

Language: English

Topic: Porphyrin Metabolism and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414290578