Work

Mannose‐Inspired Mesoionic Carbenes: Building Antitumor Palladium(II) Allyl Complexes

Year: 2025

Type: article

Abstract: The synthesis and anticancer evaluation of palladium(II) complexes bearing mannose‐conjugated mesoionic carbenes and their triazolium precursors (triazolium palladates) is reported. Ligand precursors are easily obtained via copper‐catalyzed azide–alkyne cycloaddition. Palladium allyl carbene complexes are prepared extending the weak base route protocol to triazolium salts by reacting the metal precursor and azolium salts with potassium carbonate as the base in acetonitrile and under mild conditions. Additionally, triazolium allyl palladates are isolated, which represent the first examples of triazolium palladate complexes described in the literature. In vitro tests on a panel of cancer cell lines (A2780, A2780cis, DLD‐1) reveal better or comparable cytotoxicity to cisplatin. The majority of complexes exhibit low cytotoxicity (>100 μM) toward MRC‐5 and FT‐190 nontumoral cell lines demonstrating remarkable in vitro selectivity.

Source: European Journal of Inorganic Chemistry

DOI: 10.1002/ejic.202500382

Authors: Giovanni Tonon, Martina Scianna, Isabella Caligiuri, Flavio Rizzolio, Fabiano Visentin, Thomas Scattolin

Institutions: Ca' Foscari University of Venice, Centro di Riferimento Oncologico, University of Padua

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,050