Well‐Defined Rhodium and Iridium Complexes Containing Chiral Cyclic(Alkyl)(Amino)Carbenes for Asymmetric Hydrogenation
Year: 2025
Type: article
Abstract: A novel class of well-defined rhodium and iridium complexes containing various chiral cyclic(alkyl)(amino)carbene (ChiCAAC) ligands has been synthesised and fully characterized. While no enantioselectivity was observed with chiral Rh-CAAC, the Ir-CAAC counterparts demonstrated good performances in the asymmetric hydrogenation of various allylic alcohols and derivatives with up to 86% ee. Mechanistic studies, including deuteration experiments revealed that the reduction proceeds via direct alkene hydrogenation rather than via isomerization.
Source: ChemistryEurope
Authors: Fanny Morvan, Meng Liu, Thomas Vives, Thierry Roisnel, Nicolas Vanthuyne, Rodolphe Jazzar, Joanna Wencel‐Delord, Marc Mauduit
Institutions: Centre National de la Recherche Scientifique, Institut des Sciences Chimiques de Rennes, École Nationale Supérieure de Chimie de Rennes, Université de Rennes, Aix-Marseille Université, Centrale Méditerranée, University of California San Diego, UCSD-CNRS Joint Research Chemistry Laboratory, University of Würzburg
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4414298591