SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease
Year: 2025
Type: article
Study design: Observational Study
Abstract: Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SECTM1), a monocyte chemoattractant, to be our top novel finding associated with incident CHD. We validated our findings in the Cardiovascular Health Study. The top variant (rs116473040) associated with SECTM1 was associated with circulating monocyte percentage of white blood cells in a genomic database. In vivo studies demonstrated that recombinant SECTM1a increased the proportion of proatherogenic Ly6Chi monocytes, suggesting a pathway by which SECTM1 may contribute to CHD.
Authors: Usman A. Tahir, Daniel Cruz, Dongxiao Shen, Gaurav Tiwari, Jing Liu, Matthew Huber, Christopher Chan, Shuliang Deng, Mark D. Benson, Jeremy Robbins, Zsu Zsu Chen, Laurie Farrell, Lynette Ekunwe, Michael Hall, Bruce M. Psaty, James S. Floyd, Aarti Asnani, Filip K. Swirski, James G. Wilson, Robert E. Gerszten
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,750
OpenAlex ID: W4414301609