Work

Maximal-effort knee-extension exercise impairs skeletal muscle oxidative capacity and V o 2 recovery in vivo

Year: 2025

Type: article

Abstract: We measured rates of skeletal muscle V̇o 2 recovery ([Formula: see text]) at baseline and following fatiguing exercise using near-infrared diffuse correlation spectroscopy (NIRS-DCS). Regardless of whether [Formula: see text] was measured via the conventional repeated arterial occlusion method ( part A) or a novel NIRS-DCS “free-flow” method ( part B), fatiguing exercise impaired [Formula: see text] by ∼15%–25%. Because ATP demand rapidly declines post exercise, the slow [Formula: see text] recovery observed here suggests fatiguing exercise may uncouple the functional relationship between mitochondrial O 2 consumption and ATP synthase activity.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00517.2025