Work

Vascular epilepsy in adulthood: current status and outlook for research and management

Year: 2025

Type: article

Abstract: Background Vascular epilepsies can manifest at various stages of adulthood and are often accompanied by age-related comorbidities. Aging processes, particularly vascular and neurodegenerative changes, contribute significantly to the risk of late-onset epilepsy (LOE). Methods This narrative review explores the emerging role of the glymphatic system in the pathogenesis of vascular-related adult-onset epilepsy in the context of aging. Both established antiseizure medications (ASMs) and novel preventive strategies currently under investigation are evaluated. Results and conclusion The review emphasizes the importance of an interdisciplinary management approach and discusses practical considerations for optimizing care in this patient population.

Source: Clinical Epileptology

DOI: 10.1007/s10309-025-00782-0

Authors: Hermann Stefan, Ernst Thilo Hammen, Vineet Punia

Institutions: Universitätsklinikum Erlangen, Westpfalz Klinikum, Cleveland Clinic

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,390