Work

Thioamides in C5 Hydrogen Bonds: Implications for Protein β-Strands

Year: 2025

Type: article

Abstract: Though thioamides are considered weaker hydrogen-bond acceptors than oxoamides, recent calculations suggest that they can enhance hydrogen bonds within the backbone of individual β-strands. We confirm this prediction through spectroscopic analysis of minimal amino-acid models. Further, incorporation of thioamides into the backbone of β-hairpin models highlights opportunities to control β-strand stability.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01310

Authors: Haoliang Zheng, Robert W. Newberry

Institution: The University of Texas at Austin

Language: English

Topic: Crystallography and molecular interactions

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Welch Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: G1314582436, G150459091, G2356012781, CHEMICAL STRATEGIES FOR CONFORMATIONAL CONTROL OF BIOACTIVE PEPTIDES