Fertility Preservation in an 18-Year-Old Female with an Ovarian Granulosa Cell Tumor: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Objective: Ovarian granulosa cell tumors (GCTs) are rare malignancies that can profoundly affect fertility, particularly in young women. This case report describes a successful fertility preservation strategy in an 18-year-old female diagnosed with a Stage I ovarian granulosa cell tumor. Methods: A multidisciplinary team implemented a fertility preservation protocol involving preoperative ovarian stimulation, oocyte retrieval, and cryopreservation. This was followed by staging laparotomy and unilateral salpingo-oophorectomy. Results: A total of 10 mature oocytes were successfully cryopreserved. Histology confirmed a Stage I granulosa cell tumor with no evidence of metastasis. The patient tolerated adjuvant therapy well and remains disease-free at follow-up. Conclusion: The successful application of controlled ovarian stimulation and oocyte cryopreservation prior to definitive surgery demonstrates the feasibility of proactive fertility preservation in hormonally active tumors when managed with careful monitoring. Furthermore, the patient’s positive postoperative course and continued disease-free status at 18 months reinforce the safety and efficacy of fertility-sparing surgical strategies in Stage I GCTs.
Source: Medical Times
Institution: Yerevan State Medical University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414326175
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